Equalizer Plus Pregnenolone Adrenal Support Cream
(Also used for Arthritis and Pain Relief)

ADRENAL SUPPORT Special Savings Packages

ADRENAL & THYROID Support for WOMEN: 1 Pump EQ+ Adrenal Arthritis Pregnenolone, 1 tube DHEA for Women 1 Pump HPMS Progesterone Cream	ADRENAL & THYROID Support for MEN: 1 Pump EQ+ Adrenal Arthritis Pregnenolone, 1 tube Men's D-35 DHEA 1 Pump Adams Men's Progesterone Cream
only $59.95  Item #8W	only $59.95  Item #8M

The adrenal support solution?  DHEA, Pregnenolone, & Progesterone at the right times in the day.

Equalizer Plus Pregnenolone MSM Glucosamine Support Cream -
Original Formula  or Mint Formula - 3 oz. pump dispenser

Ingredients: Deionized Water, Natural Glycerin, Stearic Acid, d-Alpha Tocopherol Acetate (Natural Vitamin E), Emu Oil, Methyl-Sulfonyl-Methane (MSM), Pregnenolone, Glucosamine Sulfate, Ginger, Rosemary Extract, Zinc.  Equalizer Plus™ Pregnenolone Adrenal Support Cream is also used for Pain Relief and Arthritis.  1 pump compression delivers 18-20 mg Pregnenolone depending on usage.

Formulation: Equalizer Plus is a proprietary revolutionary new cream that combines the natural, yet powerful, pain relief of Pregnenolone, Ginger Extract and Emu Oil with the cartilage and joint building benefits of Glucosamine Sulfate and MSM.
The Original formula cream is white, unlike other topical pain creams that have distinctive smells, the deep penetrating formula is odorless, in a chemical free base, non-stinging, moisturizing, fragrance free.

USE For Adrenal Support:  It is almost impossible to use too much.  Pregnenolone knows if it is needed or not and the body simply excretes any excess.  It has a relatively short cycle in the body.  DHEA & Pregnenolone in the morning; Pregnenolone throughout the day; and Progesterone in the evening, rest, good nutrition, and time are the key to restoring adrenals.  That is the normal adrenal function cycle.

Adrenal Exhaustion & Adrenal Fatigue, leading to Adrenal burnout is common.  Hormones to boost the adrenals are DHEA, Progesterone, and Pregnenolone. Using all three hormones is critical to improve adrenal function. It takes a long time to regain strong adrenals. You need the right hormones at the right time of day.  A single formula cannot be created to boost adrenals because the 3 hormones have different peak longevity cycles in the body. DHEA & Pregnenolone in the morning; Pregnenolone throughout the day; and Progesterone in the evening, rest, good nutrition, and time are the key to restoring adrenals. Creams bypass the liver and go where needed. Equalizer Plus originally developed for arthritis pain relief is superb with its high Pregnenolone formula content in an adrenal repair protocol along with DHEA and Progesterone. See How Hormones Work.

Ingredients and Research

Directions:  For Adrenal Support: Use in the morning and throughout the day.  Pregnenolone is one hormone that you cannot get too much of.  What the body does not need, it excretes very quickly.

Pregnenolone edited by Dan Milosevich, C.N. (Thank you, Dan, Your write up makes the most sense of all)

When pregnenolone was discovered in the 1930's, researchers at first thought it was an inert substance, because when they gave it to healthy young animals, it had no effect. Further studies in the 30's and 40's showed pregnenolone to be a most promising supplement for preventing and curing stress-related maladies. This indicates an amazing quality of pregnenolone: it does not cause problems when taken even if not needed, but when needed it can quickly and profoundly restore balance to the basic stress chemistry of the body. This is especially important today, as some researchers propose that unrelieved stress is the major contributing factor to chronic illness.

Before it was pushed aside by the promotion of other hormones such as cortisone and their analogs such as prednisone, pregnenolone was known to have a wide range of beneficial actions for people who were sick or under stress. These included helping arthritic conditions, countering fatigue, adrenal replenishment, and in general improving the quality of life and awareness. Because it occurs naturally, it cannot be patented. We now know that these other patentable chemicals, even though promoted as "wonder drugs", have very bad side effects.  Pregnenolone at worst will have no effect - in healthy, unstressed subjects - and in sick or stressed people, will promote the correction of such problems as these. Reputable researchers such as Ray Peat, Ph.D., can find no unbalancing or deleterious effect even with large doses of pregnenolone.

Although DHEA is the most abundant naturally-occurring hormone in the human body, the real "Mother Hormone" is pregnenolone, not DHEA. The internal synthesis of steroid hormones begins when the body converts cholesterol to pregnenolone, creating the basic hormonal substance. From pregnenolone, there are two major pathways: one toward DHEA and one toward progesterone. The hormones in the progesterone pathway, including aldosterone, cortisol and progesterone itself, are not directly derivable from DHEA. This means that although DHEA can be a remarkable help in the case of DHEA, estrogen, or testosterone deficiency, the truly balancing hormonal substance is pregnenolone. In fact, even when taking DHEA, better results may be obtained by taking pregnenolone as well.

Pregnenolone levels, like DHEA levels, decline with age. It is present in young people of both sexes at a very high level, in part due to the fact that it is one of our basic defenses against the harmful side effects that an imbalance of even our natural hormones can produce. For instance, when there is an abundance of pregnenolone, the side effects of excessive cortisol or estrogen are prevented or minimized. By the age of 30, men and women typically produce 30 to 50 mg. of pregnenolone a day. Taking pregnenolone does not cause masculinizing effects in women, like high levels of DHEA can, because it is much less likely to increase testosterone levels.

Recent studies indicate that it may also be the most potent and quick-acting brain nutrient ever found, working in part through its impact on N-methyl-D-aspartate receptors in the brain. It blocks the inhibitory amino acids glycine and GABA, helping to balance excitation and inhibition in the central nervous system. As early as the 1940's, human studies demonstrated that it improved performance of ordinary physical and mental tasks, and we now know why: pregnenolone is one of the major hormones in the brain. It is concentrated there, and some of it is produced by certain brain cells. It continues it's basic role even here, protecting brain cells from injury caused by fatigue. It likely has other important roles in the brain which we have yet to discover.

According to Peat, pregnenolone very quickly helps fatigued, stressed people regain their ability to handle stress, sometimes with a single dose. He has noticed that it can keep acting for as long as a week, and he theorizes that absorption continues along the intestine and "recycles" it in the body. It may even improve the body's ability to produce its own pregnenolone. It also tends to improve function of the thyroid and other glands. It can have a calming effect on the emotions, giving a mood of resilience and an ability to confront challenges. Also, people have noticed that pregnenolone has a "face-lifting" action, produced by improved circulation to the skin, and by an actual contraction of some muscle-like cells in the skin. A similar effect can improve joint mobility in arthritis, tissue elasticity in the lungs, oxygen depletion in emphysema, and even eye conditions, including the bulging eyes of Graves disease.

The conversion of cholesterol to pregnenolone is aided by the presence of sufficient vitamin A, vitamin E, thyroid hormone, copper, and light, and can be blocked by too much estrogen, X-rays, ultraviolet light, unsaturated oils, and iron. From reports we have heard, it seems to be easily absorbed when taken orally. Of the many supplements which are important components of a good health plan, pregnenolone stands out as one of the best. It is a natural nutritional substance that is powerfully beneficial and yet utterly safe. If you are taking any adrenal hormones, you may want to take pregnenolone along with them. If you are still considering taking DHEA or other hormones, consider trying pregnenolone first.

Bioidentical Hormones for Adrenal Support

Source of Adrenal Exhaustion diagram is Dr Lam at www.LamMD.com, one of the foremost authorities on the aging process.  Read his full article .

The hormones needed to support the adrenals in the varying stages of Adrenal exhaustion, stress, fatigue, and burnout are Pregnenolone, DHEA, and Progesterone.  See How Hormones Work.

Glucocorticoids, primarily cortisol, are produced by the adrenal glands in response to stressors such as emotional upheaval, exercise, surgery, illness or starvation. Cortisol plays an essential role in immune function, mobilizing the body's defenses against viral or bacterial infection, and fighting inflammation; however, chronic elevated cortisol levels suppress the action of the immune system and predispose to frequent infections. Cortisol levels are highest first thing in the morning, to combat the stress of overnight fasting and to animate the body for the day's activities.

The brain derives most of it's energy from glucose, so maintenance of adequate blood levels is a top priority. After a period of fasting, cortisol output increases, and this initiates catabolism, or the breakdown of protein into simple amino acids and their conversion into glucose to feed the brain.

Chronic, excessive stress (emotional or physical), protein deficiency, and lack of nutrients including Vitamins A, C, and Pantothenic acid (B5) can cause the adrenal glands to become exhausted, so that they can no longer produce adequate cortisol. This leads to low blood glucose (hypoglycemia), excessive fatigue, and increased susceptibility to infection.

Tightly coordinated production of adrenal glucocorticoids is essential for optimal health. In normal individuals, the breakdown or catabolism of tissues by glucocorticoids is followed by the building up or anabolism of tissues by androgens. As we grow older, an excess of catabolic hormones over anabolic hormones develops, and this is in part responsible for the aging of all the body tissues, and the loss of our ability to repair damaged tissue. The same thing happens under chronic, excessive stress, and contributes to premature aging. Stress can literally burn our bodies out prematurely.

Why Equalizer Plus works so well:

• Pregnenolone is a natural hormone made primarily in the adrenal glands and is actually a derivative of cholesterol.  It is the "Mother of All Hormones". See How Hormones Work . Under the Dietary Supplement Law of 1994, Pregnenolone is classified as a nutrient and, is available to the general public without health care provider's order.  Its benefits to sufferers of both osteoarthritis and rheumatoid arthritis date back to the 1950's.  900 mg.

• Ginger is a natural herb that possesses many therapeutic properties.  The most relevant to arthritis sufferers, particularly those with rheumatoid arthritis, is its ability to inhibit inflammation and bring immediate relief from pain.  6000 mg.

• Emu Oil, used by the Aboriginal people of Australia for the treatment of muscle and joint pain, contains a variety of fatty acids.  Modern research into the properties of emu oil has found that this is the greatest skin emollient in the world, with deep skin penetration properties better than any other natural oil.  100 IU per 1/4 tsp.

• Glucosamine Sulfate - Glucosamine is a naturally occurring substance normally formed from glucose and found in high concentrations in joint structures.  As people age, they lose some of the glucosamine and other substances in cartilage.  This can lead to the thinning of cartilage and the onset and progression of arthritis. 
  Glucosamine Sulfate - the preferred form of glucosamine, works at both relieving pain and stimulating healing.  It provides the raw materials used by the body to make cartilage and connective tissue which helps to provide cushioning and lubrication for each of the body's joints.  More than 300 scientific investigations and over 20 double-blind, placebo-controlled studies have been conducted on this nutrient.  The conclusion:  It works at both relieving pain and stimulating healing.  One study reported that it reduced pain more effectively than ibuprofen. (Current Medical Research & Opinion 8:145-149, 1982)  9,000 mg.

• Menthyl Sulfonyl Methane - or MSM.  A natural form of organic sulfur found in all living organisms.  MSM is supplied to the human body, through a variety of fresh foods including fruit, vegetables, meat, eggs, fish and milk.  MSM is the flexible bond between proteins that keeps new blood cells from becoming rigid and helps tissues retain their flexibility.  Because there are few nerves in the bones, our pain comes from the soft tissues.  Aspirin shuts off the nerves, but the tissues are still damaged.  MSM relieves the inflammation, helps the tissues to heal, and prevents soreness.  MSM is a free radical scavenger, so allergies to foods and pollens will go away.  Any excess MSM in your system will stay in your blood stream for 12 hours and remove toxins, clean the interior walls of arteries and provide the body with health-giving benefits without any nuisance side effects.  Clinical research confirms that MSM is capable of reducing or eliminating leg and back cramps, general soreness and muscle spasms.  9,000 mg.

• Devil's Claw and Yucca in the new deep Penetrating Peppermint formula are well documented for their healing, repair, and regenerative effects.

• Pregnenolone is a natural hormone, is considered to be a food derivative and is available without a health care provider's order. As mandated by The Dietary Supplement Law of 1994, Pregnenolone is marketed as an over-the-counter nutrient. The benefits of Pregnenolone for sufferers of both osteoarthritis and rheumatoid arthritis date back to the 1950’s. In 1950, Dr. Harry Freeman and his colleagues from the Worcester Foundation for Experimental Biology in Shrewsbury, Massachusetts, conducted a study of 62 patients (17 men and 45 women) suffering from rheumatoid arthritis. The average age of the patients was 48 years and most had suffered with the disease for 10 years. Each patient was given 500 mg of Pregnenolone daily for a period of 2-30 weeks, 24 patients experienced striking improvement, 20 showed minor improvement, and 14 showed no improvement. There was a tendency to relapse when the medication was discontinued. (Freeman H, Pincus G, et al. Oral Steroid Medication in Rheumatoid arthritis. J Clin End 10:1523-32, 1950.)

Special Savings Packages: Pre-Packaged to give you Maximum Results!
PROGESTERONE Support: Women of all ages.	best seller! ESTROGEN Support: For Mature Women	ADRENAL & THYROID Support for WOMEN	ADRENAL & THYROID Support for MEN:
only $34.95 Item #9P	only $59.95  Item #9E	only $59.95  Item #8W	only $59.95  Item #8M
TESTOSTERONE Support Special for WOMEN	TESTOSTERONE Support Special for MEN	More Info SALIVA HORMONE TESTS  Home Collection Kits Basic Kit: 1 kit tests 2 hormones $59.95 Item # 9Z1kit Hormone Panel I Kit tests 5 hormones Panel I $149.80 (# 9Z5) Panel III Kit "the works" tests 8 hormones Panel III $239.80 (# 9Z8)
only $39.95  Item #9W	only $39.95  Item #9M

HIGHLIGHTS of the RESEARCH STUDIES

Women's Health Initiative & National Institutes Health Studies
Serious Health Risks of the Prescription Synthetic Hormones
Women's Health Initiative WHI Study site: http://www.whi.org and Studies: http://www.whi.org/findings/

New England Journal of Medicine: http://content.nejm.org
Journal of the American Medical Association: http://www.ama-assn.org
National Institutes of Health: http://www.NIH.gov

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